Cytotoxic Activity and Phytochemical Constituents of Macrosolen bidoupensis Tangane & V.S. Dang

Kieu Hung LE,Tran Canh NGUYEN,The Anh NGUYEN,Nu Dan Phuong NGUYEN,Thi Hong Tuoi DO,Le Thanh Tuyen NGUYEN,Van Son DANG,Trong Duc TRAN,Nhat Minh PHAN,Trong Dat BUİ,Dinh Tri MAİ,Tan Phat NGUYEN

Özet

Phytochemical investigations of the whole plants of Macrosolen bidoupensis Tangane & V.S. Dang, a new species discovered in Viet Nam were conducted and led to the purification of ten compounds, comprising three lupane-type (1-3), three friedelane-type (4-6), and one glutinane-type (7) triterpenoids and three cholestane-type steroids (8-10) using various chromatographic methods. Their structures were characterized by HR-ESI-MS, NMR experiments and comparison with previous literature. Compounds 1, 3 and 5 expressed moderate cytotoxicity against two tested cell lines - MDA-MB-231 and RD (IC50 ranged from 34.19 to 74.25 μM), whereas compounds 4 and 6 exhibited selective cytotoxic activity (IC50 ranged from 29.07 to 45.20 μM).