A New Phenylpropanoid from the Roots of Solanum melongena L. and Evaluation of Anti-inflammatory Activity

Özet

Fifteen phenylpropanoids were isolated from the ethanol extract of Solanum melongena L. roots, including a new compound, melongenapanoid A (1), and fourteen known compounds (2-15) were isolated from the species. Their chemical structures were elucidated by interpreting the 1D and 2D NMR and HR-MS data as well as in comparison with the literature. The anti-inflammatory activities of isolates were evaluated by measuring their inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW 264.7 cell line. Compounds 2, 4 and 5 showed potential inhibition of NO production with IC50 values of 28.7, 24.4 and 32.6 μM, respectively.