Synthesis of Certain New Morpholine Derivatives Bearing a Thiazole Moiety

Özet

Morpholine is a synthetic simple heterocyclic organic compound having characteristic functional groups of amine and ether. Feasible physicochemical properties (polarity and solubility), low cost and wide availability make it a suitable candidate for the synthesis of many potent drugs. In our work, we synthesized a new series of thiazole substituted morpholine derivatives in two steps. In the first step, thiourea was synthesized in THF at 70-75OC for 24 h and then in the second step the formation of thiazole ring was ensured in EtOH-DMF (5:5 v/v) at 60°C for 24 hours.