Dergiler / Optimal Tıp Derg. / 2002 / Cilt: 15 - Sayı: 2
Plasma protein C, protein S, antithrombin-III and fibronogen levels of children with beta thalesemia major
- Dergi
- Optimal Tıp Derg.
- Sayfa
- 35–40
- DOI
- —
Özet
Protein C, Protein S ve Antitrombin III, koagulasyon ve antikoagulasyon arasındaki dengenin sürdürülmesinde görev alan önemli doğal antikoagulanlardır. Talasemik hastalardaki tromboemboli riski, normal populasyondan daha fazladır. Bu çalışmanın amacı, Talesemi majorlü çocuklarda hemostaz ve tromboz parametrelerinin bir kısmını araştırmak ve tromboembolik hasarın sebeplerim anlamaktır. Protein C, Protein S ve Antitrombin IH düzeyleri, Beta talesemi majorlü 43 hastadan ve 40 sağlıklı çocuktan alınan plazma örneklerinde koagulometre cihazında çalışıldı. Hasta ve kontrol grubunun Protein C aktivite düzeyleri sırası ile % 50,5420,13 ve % 94,66±32,62 olarak ölçüldü. Hasta ve kontrol grubu arasındaki farkılılıklar istatistiksel olarak anlamlıydı (p 0,05). Hasta grubunda Protein S ve Antitrombin III düzeyleri arasında pozitif bir ilişki gözlendi (p<0,05). Kontrol grubunda, protein C-Protein S arasında (p<0,05) ve Protein C ile fibrinojen arasında negatif bir ilişki bulundu (p<0,05). Elde edilen bu veriler Beta talesemide doğal anticoagulanların azaldığını belirtir.
Abstract
Protein C and Protein S and Antithrombin-HI, are natural anticoagulant, most of the important element that maintain equilirium between coagulation ve anticoagulation. The risk ofthromboemboly of thalasemic patients is much more greater than normal population. The purpose of this study was to investigate some of hemostasis and thrombosis parameters of children with thalassemia major and introducing and understanding of reasons for tromboembolic damage. Protein C, Protein S and Antithrombin 111 levels were analysed by coagulometer of plasma from 33 Thalessemia major and matched 30 health children. Protein C activity levels of patients and the control group were measured as %50.54±20.13, and %94.66±32.62 respectively. The differences between patients and the control group was statistically significant. (p<0.001). Protein S activity levels of patients and the control group was 53.16+27.46 %, and 74.46+20.19 % respectively.(p<0,001) Antithrombin-III levels of patients was 94.51+20.02 % and the level of control group was 119.33±11.70 %.(p<0.001) Fibrinogen levels of patients and the control group were 239.06+61.48 mg/dL, 269.93±72.50 mg/dL respectively.(p>0.05) In patient group a positive relation was found between Protein S and Antithrombin-III levels.(p<0,05) In control group a negative relation was found between Protein C-Protein S (p<0,05) and a negative relation found between Protein C-flbrinogen.(p<0.05) These data indicate that naturel anticoagulants are decrease in beta-thalassemia. Consequently, oral anticoagulant and mini dose heparin can be applied in the treatment of venous thrombosis and Protein C and Antithrombin-III replacement treatment can be applied additionally.