Dergiler / Organic Communications / 2019 / Cilt: 12 - Sayı: 2

Oxidation of hesperidin into diosmin using ionic liquids

V. Thanh NGUYEN,T. Kim Chi HUYNH,Thanh Danh NGUYEN,T. Kim Dung HOANG

Sayfa
101–108
DOI
—

Özet

In this study, ionic liquids (ILs) were used as green solvents for the conversion of hesperidin into diosmin for the first time. Specifically, diosmin was synthesized via the oxidation of hesperidin with iodine inIls including [BMIM]Br, [BMIM]BF4, [BMIM]OTf, [BPY]Br, [BPY]BF4and [BPY]OTf. The process allows obtaining diosmin with high yields of 79-85%, in which, [BPY]Br and [BPY]BF4exhibited excellent solvent properties for the oxidation of hesperidin even after several recycling cycles. Furthermore, it was found that the presence of water in recycle ILs from 1-5 % (v/v) induced a significant increase in diosmin yields.