Synthesis of Trisubstituted Imidazoles Using Lewis and Bronsted Acid Catalysts

Abstract

An efficient and one-pot method for the preparation of trisubstituted imidazoles by condensation of benzil, different aldehydes and ammonium acetate in the presence of a catalytic amount of NiSO4.7H2O or H3BO3 under different conditions is reported. Key Words: Trisubstituted imidazoles, Multi-component reactions, NiSO4.7H2O, H3BO3, one-pot reactions, solid acid catalysts.