Dergiler / GORM:Gynecology Obstetrics & Reproductive Medicine / 2000 / Cilt: 6 - Sayı: 2
Combined use of serum CA 125 and CA 15-3 in the follow-up of patients with epithelial ovarian cancer after primary cytoreduction and correlation with second look laparotomy
- Sayfa
- 128–131
- DOI
- —
Özet
Bu çalışmadaki amacımız epitelyal over kanserinde primer sitoredüksiyon sonrasında serum CA 125 ve CA 15-3 seviyelerinin kombine kullanımının ikinci bakı laparatomi ile korelasyonunu tanımlamaktır. 25 hastada prospektif olarak preoperatif dönemde, postoperatif 10. günde ve ikinci bakı laparotomi öncesinde serum CA 125 ve CA 15-3 seviyeleri ölçüldü. Postoperatif dönemde heriki tümör belirteci de anlamlı bir şekilde azaldı (p<0.01). Preoperatif ve postoperatif serum CA 125 ve CA 15-3 seviyeleri arasında anlamlı korelasyon saptandı (r=0.622, p=0.001 ve r=0.645, p<0.001, sırasıyla). Lojistik regresyon analizine göre serum CA 125 ve CA 15-3 seviyeleri ikinci bakı laparotomi sonuçlarının önceden tahmininde kullanılabileceği sonucuna varıldı (r=0.068, p<0.05 ve r=0.175, p<0.01, sırasıyla).
Abstract
OBJECTIVE: In order to define the combined use of serum CA 125 and CA 15-3 in the follow-up of patients with epithelial ovarian cancer after primary cytoreduction and its correlation with second look laparotomy. STUDY DESIGN: Serum CA 125 and CA 15-3 levels were prospectively measured in 25 patients preoperatively, on the 10th postoperative day, and before the second look laparotomy. RESULTS: In the postoperative period, mean values of both tumor markers decreased significantly (P<0.01), and a significant correlation was noted between preoperative and postoperative serum CA 125 and CA 15-3 levels (r=0.622, p=0.001 and r=0.645, p<0.001, respectively). Logistic regression analysis indicated that serum Ca 125 and CA 15-3 levels predicted the results of second look laparotomy (r=0.068, p<0.05 and r=0.175, p<0.01, respectively). CONCLUSION: CA 15-3 is effective both for the diagnosis before the primary cytoreductive surgery, and for the follow-up thereafter; and sensitivity and negative predictive values are increased when combined with CA 125. (Gynecol Obstet Reprod Med 2000; 6:128-131]^^.