Dergiler / GORM:Gynecology Obstetrics & Reproductive Medicine / 2000 / Cilt: 6 - Sayı: 2
The effects of medroxyprogesteron acetate and dydrogesterone added to the transdermal system on sex hormone binding globulin, serum lipid and lipoproteins
- Sayfa
- 112–115
- DOI
- —
Özet
Transdermal hormon replasman tedavisine eklenen medroksiprogesteron asetat ve didrogesteronun reprodüktif hormonlar ve serum lipidlerine etkilerini saptadık. Dokuzuncu ayın sonunda her iki grupta da FSH ve LH başlangıç değerine göre anlamlı oranda düşerken SHBG ve E2 düzeyi anlamlı oranda artmış olarak saptandı (p 0.05). Medroksiprogesteron ve didrogesteronun siklik verimi postmenopozal dönemde lipid ve lipoproteinler üzerine benzer etkiler yapmaktadır.
Abstract
OBJECTIVES: Our main objectives were to determine the effects of dydrogesteron and medroxyprogesteron asetat (MPA) added to the transdermal hormon replacement therapy (HRT), on the levels of reproductive hormones and serum lipids in postmenopausal period. STUDY DESIGN: Subjects were randomly divided into two groups which received transdermal estradiol and oral MPA or dydrogesteron in Group I or in Group II respectively, in a cyclic treatment protocol. Student's t test was used for the statistical analyses. RESULTS: When the levels obtained after a 9 months HRT period are compared to the starting levels within each group, significant decreases in FSH and in LH values were found, whereas E2 and sex hormone binding globulin (SHBG) levels were increased in both groups (p<0.05). Also, an increase in Apo A-l levels in group I and decreases in TC and LDL-C levels in both groups were found (p<0.05). However, no statistical difference was found between the levels of two patient groups (p>0.05). CONCLUSION: Cyclic administration of MPA or dydrogesteron, added to the transdermal E2 therapy had similar effects on SHBG, serum lipids and lipoproteins in postmenopausal women. (Gynecol Obstet Reprod Med 2000; 6:112-115)/*~*