Dergiler / GORM:Gynecology Obstetrics & Reproductive Medicine / 2003 / Cilt: 9 - Sayı: 3
Elevation of total plasma cortisol with preterm premature rupture of the membranes
- Sayfa
- 165–167
- DOI
- —
Özet
Doğum eyleminde olmayan preterm prematür membran rüptürlerinde plazma kortizol seviyeleri araştırıldı, ve istatistiksel olarak kontrol grubuna göre anlamlı bir yükselme olduğu görüldü (ortalama cortizol seviyesi=48.2±16.2 mcg/dl; kontrol kortizol seviyesi=32.0±3.3 mcg/dl). Plazma cortizol seviyesindeki bu artis prematür membran rüptürlerinde doğum eyleminin ilk etyolojik göstergesi olabilir
Abstract
Total plasma cortisol levels (CT) were determined in patients with preterm premature rupture of the membranes (PPROM) who were not in labor. Overall, CT was significantly elevated following PPROM as compared to patients with intact membranes who delivered at term. The CT levels were independent of the gestation at which PPROM occurred. Elevation of cortisol in patients with PPROM may reflect uterine contractility as a primary etiology for this occurrence, and may signal impending labor or may indicate dysregulation of the hypothalamic-pituitary-adrenal axis. OBJECTIVE: To study the variation of total plasma cortisol (CT) in patients with preterm premature rupture of the membranes (PPROM) who are not in labor. STUDY DESIGN: CT was determined from ten patients with confirmed PPROM in singleton pregnancies between 23-35 weeks gestation. Six patients were followed with serial determinations until the onset of labor. RESULTS: CT was significantly elevated (mean CT=48.2±16.2 mcg/dl) in patients with PPROM relative to term patients with intact membranes who also were not in labor (mean CT=32.0±3.3 mcg/dl). Little gestational variation in CT was seen. In two patients who went into labor, further elevation in CT was seen. CONCLUSIONS: Plasma cortisol is elevated in patients with PPROM. The primary etiology for this occurrence may reflect underlying uterine contractility preceeding the onset of labor.