Influence of hypoglycemia during the 100-G oral glucose tolerance test on onstetrics outcomes

100-G oral glukoz tolerans testi sırasında hipogliseminin obstetrik sonuçlara etkisi

İnegöl İlknur GÜMÜŞ,Feridun KARAKURT,Ayşe KARGILI,Carda Neslihan SEÇKİN,Hasan KAFALI,Öztürk Nilgün TURHAN

Özet

Gebelikte 100-g oral glukoz tolerance testi (OGTT) sırasında gelişebilecek hipogliseminin perinatal sonuçlara etkisini araştırmak. Bu retrospektif çalışmada 411 gebe değerlendirildi. Ges-tasyonel diabetes mellitus tanısı alan 31 hasta (%7,5) ekarte edildi. Çalışma grubunu 100-g oral glukoz tolerans testi 3.saat sırasında 60 mg/dL ve altı espit edilen hastalar, kontrol grubunu ise hipoglisemi tespit edilmeyen hastalar oluşturdu. 100-g oral glukoz tolerans testi sırasında 62 hipoglisemik (%15) hasta tespit edildi. Kontrol grubu olarak 318 hasta toplandı. Gebelikte toplam alınan kilo hipoglisemik grupta daha fazla tespit edildi (p=0.019). Ortalama bebek doğum ağırlığı hipoglisemik grupta 3419±421,9 g, kontrol grubunda 3275± 491,7 g idi (p=0.042). Yenidoğan yoğun bakıma kabul oranı iki grupta da benzer idi. OGTT sırasında hipoglisemi tespit eden gebelerde gebelikte alınan toplam kilo daha fazla bebek doğum ağırlığı daha fazla tespit edildi. OGTT sırasında hipoglisemi tespit edilen gebeler daha dikkatlice takip edilebilir.

Abstract

OBJECTIVES: We aimed to investigate the impact of hypoglycemia during 100-g oral glucose tolerance test on perinatal outcomes. STUDY DESIGN: Obstetrics records of 411 pregnants who delivered singletons at our institution were reviewed. 31/411 (7,5 %) of patients who were diagnosed as Gestational Diabetes Mellitus were excluded from the study. The study group was consisted of pregnant women who experienced hypoglycemia defined as a plasma glucose level of 60 mg/dL or less during the 100-g oral glucose tolerance test. This group were compared with women who had normal glucose levels during 50-g oral glucose loading test (glucose challenge test) and who had normal values and had no hypoglycemia during 100-g OGTT. RESULTS: We identified 62 hypoglycemic patients (15 %) on 100-g oral glucose tolerance test and 318 non-hypoglycemic patients (77,3 %) as control group. Gestational weight gain was statistically higher in hypoglycemic group. The mean birth weight was 3419±421,9 g in the study group and 3275±491,7 g in the control group (p=0.042). Rates of babies admitted to NICU were similar in both groups. CONCLUSIONS: Women who experience hypoglycemia during the OGTT have a significantly higher incidence of gestational weight gain and higher neonatal birth weights as well. As a result if a pregnant has hypoglycemia during OGTT we should monitorize her and the fetus as well carefully.