Evaluation of the Relationship Between Platelet Indices and Mitral Restenosis After Percutaneous Mitral Balloon Valvuloplasty

Özet

Objectives: Percutaneous mitral balloon valvuloplasty (PMBV) has been established as an effective and safe treatment modality for symptomatic patients with severe rheumatic mitral stenosis. Wilkin scores ≤8 are associated with higher rates of procedural success and lower rates of restenosis. It is well-known that platelets have a substantial role in thromboembolic complications of rheumatic mitral stenosis and various studies have showed that increases platelet (PLT) activity in rheumatic mitral stenosis. The aim of this study was to assess the usefulness of PLT indices as a predictor of restenosis in patients who underwent PMBV. Materials and Methods: We retrospectively enrolled 178 consecutive patients who underwent PMBV. Patients were classified into two groups. The study group (n=21) included patients whom we performed redo PMBV during their followups as a result of mitral restenosis following previous PMBV (index procedure) and the control group (n=157) included patients who did not undergo a redo PMBV. PLT indices including PLT count, Plateletcrit (PCT) and mean platelet volume (MPV) values were evaluated in these groups. Results: In the study group, PLT count (210±49 vs 241±62, p=0.010), PCT [0.203 (0.173-0.230) vs 0.260 (0.243-0.290), p<0.001] and MPV [9.7 (8.7-11.1) vs 10.5 (9.8-12.0), p=0.021] values were significantly higher in the restenosis group when compared to the control group. Receiver operating characteristic analysis showed cut-off values for MPV crossed the curve at 9.65 (sensitivity 81.0% and specificity 49.7%) and for PCT crossed the curve at 0.241 (sensitivity 76.2% and specificity 87.9%). Conclusion: PLT indices including PLT count, MPV and PCT might be feasible and easy parameters to predict possible restenosis after PMBV.