Effects of topical hyaluronic acid (Sepragel®/Hylan B) on mucosal healing after endoscopic sinus surgery

Abstract

Objective:To investigate the effects of hyaluronic acid (HA)(Sepragel®Hylan B; Genzyme Co., Cambridge, MA, USA) on themucosal healing of patients who undergone functional endoscopicsinus surgery (FESS) for chronic rhinosinusitis and/or nasal polyposis. Methods:A total of thirty-six patients were included in the study.Patients had received topical administration of HA soaked sponges tothe middle meatus on one side of their nasal cavities intra-operativelyat the end of the procedures. Other side of the middle meatus was freeof any treatment or packing to create a control group. Postoperativeendoscopic examination was performed at the 1st, 4th and 12th weeksin order to score mucosal findings regarding synechiae, mucosal hypertrophy and polyp formation on both sides. Mucosal findings werescored from 0 to 3 points (0: lesion free, 1: mild, 2: moderate, 3: severe). Results: Average scores of the mucosal cavities were compared and itwas found to be significantly low for the HA administered mucosa(p< 0.05). Synechia formation and mucosal hypertrophy at the 1st, 4thand 12th weeks were significantly low for the Hylan B group compared to the control group (p< 0.05 for both findings). Conclusion:Topical HA has preventive effects on synechia formation and mucosal hypertrophy