Evaluation of the Relationship Between Resting Heart Rate and Endocan, Thrombomodulin Levels in Healthy Adults

Özet

Objectives: Resting heart rate (RHR) is a physiological parameter that has been reported to be associated with endothelial dysfunction. Endocan and thrombomodulin are mediators released from endothelium, which are determined to increase in blood with endothelial damage. We aimed to investigate the relationship between RHR and these biomarkers. Materials and Methods: Sixty-eight healthy volunteers (28 females; mean age: 44.2±6.3 years) were included in the study. Subjects divided into two groups according to heart rate quartiles: lower two quartiles as group 1 (n=35,) and upper two quartiles as group 2 (n=33). Endocan and thrombomodulin levels in blood of the individuals were measured. Results: Clinical features and laboratory findings were similar in both groups (p>0.05 for all variables). Mean RHRs were 70.9±4.9 in group 1 and 84.8±4.3 in group 2. No statistically significant difference was found in endocan and thrombomodulin levels in both groups (p>0.05 for all variables). No significant correlation was detected between RHR and these molecules. Conclusion: RHR was not associated with endothelium derived biomarkers endocan and thrombomodulin.