The Relation Between Thyroid Stimulating Hormone and Left Ventricular Strain Parameters in Patients with Subclinical Hypothyroidism

Özet

Objectives: In this study, it was aimed to evaluate the relationship between serum thyroid stimulating hormone (TSH) level and left ventricular strain parameters measured by the two-dimensional speckle tracking imaging among adults with subclinical hypothyroidism (SH). Materials and Methods: Forty patients with SH were divided into two groups according to TSH level (the first group: TSH values of 4.2-10.0 mIU/L; the second group: TSH values >10 mIU/L). Besides, 20 (control group) ageand gender-matched healthy subjects were included in the study as the control group. Standard echocardiographic measurements and the two-dimensional speckle tracking imaging measurements of apical two and four cavities, systolic peak longitudinal strain (PLS) from shortaxis images, peak circumferential strain (PCS), global longitudinal strain and global circumferential strain were obtained. Results: Twenty patients were included in each group. In two-dimensional speckle tracking, PLS in the twodimensional speckle tracking imaging was shown to be significantly lower (p<0.001) in the second group (-18.76±1.22%) compared to the first (-20.94±1.87%) and control group (-22.18±2.02%) patients. PCS value was found to be significantly lower (p<0.001) in the patients with SH (-22.63±1.74% for the first group, -22.23±1.21% for the second group) compared to the control group (-24.24±1.59%). Conclusion: In this study, the left ventricle (LV) functions in patients with SH were evaluated by conventional and advanced echocardiographic techniques, and subclinical impairment was found in LV functions as TSH level increased.