FUNCTION OF VOLTAGE-GATED IONIC CHANNELS

Abstract

In this paper, we investigate dynamics of voltage-gated ionic channels which are of great importance in integrating the information received by neurons. Understanding of dynamical behavior of voltage-gated ionic channels plays a major role for determining underlying mechanism of spike activity and predicting the neuronal behavior. Investigation is carried out based on Hodgkin-Huxley (H-H) mathematical formalism. Ionic channel gate model is discussed briefly. Relaxation phenomenon is studied in the gate variables. Then effects of temperature on dynamics of gate variables are examined. Finally voltage-clamped simulations are carried out to determine their dynamic behaviors based on squid giant axon.