Anaplastic Childhood Meningioma in a 16-Year-Old Boy

Abstract

Introduction: Meningiomas account for 0.4-4.6% of all primary brain tumors in children. Childhood meningiomas have several different characteristics than those occuring in adults. Case: Here we report a 16 year old male presented with long-standing headache and incipient weakness on the left side. Magnetic resonance images revealed a 65x47x37 mm sized, right sided frontoparietal parasagittal extraaxial mass. Histopathologic examination showed monotonous, small cells with oval/round nucleus forming whorl like structures. Tumor showed high mitotic index and Ki67 proliferation rate around 30%. Immunohistochemically tumor cells were positive with EMA, vimentin, bcl-2, progesterone receptor. The final diagnosis according to histopathological, radiological and immunohistochemical findings was anaplastic meningioma. Conclusion: High-grade meningiomas are rare in children. Appropriate grading is important, as high grade tumors with high proliferation index are associated with less favorable clinical outcomes and warrant more radical treatment.