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This study investigated the relationship between occupational stress and psychological well-being of teachers and the moderator effects of EI, self- efficiency, coping strategies, negative affectivity social support on the relationship. Measures of occupational stress, trait EI, self-efficiency, coping strategies negative affectivity and social support were administered on 420 secondary school teachers randomly selected from Southwest Nigeria. Data were analyzed using hierarchical multiple regression. Occupational stress was negatively related to psychological well-being. The moderator variables served as protective factors for teachers who experienced occupational stress. The clinical implications of providing counselling interventions for teachers who experienced occupational stress were discussed.