American Protestant missionary society called the American Board of Commissioners for Foreign Missions (ABCFM), which was founded in Boston, state of Massachusetts in the United States of America in 1810, became one of the world's most important missionary societies by expanding fields of activity in a very short time. American Board organization had started to spread to the Ottoman lands since 1820. The Kayseri region that was among the regions needed to be paid attention of in the annual meeting of the American Board in 1850 was established as a station of the Mission of Western Turkey in 1854. This organization also gave priority to religious studies in Kayseri station as well as other regions of the mission, then training activities, in which missionaries was the most effective, started to constitute the most important fields of activity. Accordingly, Sunday schools and primary schools were established primarily. Following this, a Girls' college, and then a Boys' college were established in the Talas region in Kayseri Station. These schools in question had left an indelible impression on the religious, social, cultural, intellectual, political and economic structures of the minorities in and around Talas in a short time. In this respect, the Talas American Schools that had a history of nearly a hundred years from the beginning of their educational studies to the end of these activities, have a place where they should be dealt and examined from the point of both the Ottoman Period and Republic Period Education History. As for this study, the training system, course content, student statistics, and other information about colleges in the period from the foundation of the American boys' and girls' colleges which were established in Talas / Kayseri by the missionary organization American Board to the beginning of World War I (1914) will be examined according to American Board documentations.