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This research examines the relationship between psychological empowerment and trust in organization and supervisor. In order to find out about the relationship among study variables, a research group has been formed among the employees of three companies operating in the field of infertility treatment in medicine industry and supplying hormones for follicular development. First, variables of trust in organization and supervisor have been dealt with regarding demographic factors. It has been investigated that there is no significant difference in terms of position, experience and age, whereas, given trust in supervisor, there is a significant difference in terms of gender and education. Then, relationships between the variables have been focused on. The findings have revealed there is a strong and positive relationship between trust in supervisor and the subordinate perceptions of psychological empowerment in terms of meaning and competence factors. Trust factor as an intervening variable is thought to have an effect on the perceptions of psychological empowermen