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The Ghurids was a great and influential dynasty in Khwarezmian neighborhood.The Ghurids kings could extend their realm and appeared as a power from political, economical, cultural and military viewpoints so that Nasser-al-Din Allah (The Abbassides caliph) used them to achieve his goals and to confront his enemies specially Sultan Mohammad Khwarezm Shah. After the death of great kings of the Ghurids such as Sultan Ghias al-Din and Sultan Shahab al-Din and appearance of disputes inside this dynasty, they were killed by Sultan Mohammad Khwarezm Shah. In this article, it is tried to study the Ghurids circumstances, their weakness reason and their defeat against Sultan Mohammad KhwarezmShah by using descriptive-analytic method and valid references of controversial times.