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Since Investments in R&D have been identified as a major engine of growth by recent endogenous models, many studies have investigated the determinant R&D intensity. This paper analyzes the impact of determinant factor on the R&D investment with emphasize on openness trade by a panel data model of R&D .the result from OECD countries from 1996-2008 shows that economic growth, openness trade and R&D expenditure that funded by government have positive impact on R&D intensity while openness trade has more effect than others.