Due to the tolerant environment offered by the Ottoman Empire Mission, carried out its activities on the Ottoman soils through founding schools, religious and social institutions. Whereas in the beginning, the whole goal of those activities was to practice their religious beliefs, later Mission became a tool in the great powers struggles. Antioch was prominent for its diverse religious make – up. Moreover, its strategic location and geopolitic importance attracted the attention of great Powers. As such, Western powers competed among themselves for establishing closer relations with religious groups in the city. Groups affiliated with Missions were active in educational, health and social activities for centuries. However, they failed in their goal of Christianizing Muslims. Instead, they focused on Catholics, Protestants, Orthodox and other religious groups and tried to convince them to convert to their belief.